[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 6, Issue 3 (winter 2016) ::
J. Aqu. Eco. 2016, 6(3): 84-92 Back to browse issues page
Investigation of the effect of sublethal concentrations of endosulfan on gene expression of hypoxia-inducible factors (HIF-1 α and HIF-2 α) and vascular endothelial growth factor (VEGF) in the Persian sturgeon fingerlings (Acipenser persicus)
Hamed Kolangi Miyandareh *
Gorgan University of Agricultural Sciences and Natural Resources
Abstract:   (976 Views)
In this study, the effects of sublethal concentrations of the Endosulfan on gene expression of hypoxia-inducible factor (HIF-1 α, HIF-2 α) and vascular endothelial growth factor (VEGF) in the gill tissue of Persian sturgeon fingerling (Acipenser persicus) were studied. A total of 360 sturgeons (average weight of 2 ± 0.12 g) exposed to concentrations of 10, 20 and 40 micrograms per liter and VEGF and HIFs after 1, 2, 7 and 14 days of exposure were evaluated. The relative expression of HIF-1 α significantly increased in exposed samples in comparison to the control group. Moreover, the expression of HIF-1, 2 α in the highest concentration of toxin (40 micrograms per liter) had significantly different from other concentrations and this difference was seen in all of the sampling points. The results showed that the Endosulfan which is one of the most important pollutants in aquatic ecosystems significantly stimulates the expression of genes involved in hypoxia and angiogenesis is the gill. According to the results of this study, the devastating impact of Endosulfan on the aquatic ecosystem can be found over the past, so the basic requirement to more effective management about the use of these pesticides more than ever felt.
Keywords: Persian sturgeon, Gill, HIFs, VEGF, Endosulfan
Full-Text [PDF 856 kb]   (317 Downloads)    
Type of Study: Research | Subject: Special
Received: 2015/11/6 | Accepted: 2016/02/2 | Published: 2017/05/7
Send email to the article author

Add your comments about this article
Your username or Email:

Write the security code in the box >


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Kolangi Miyandareh H. Investigation of the effect of sublethal concentrations of endosulfan on gene expression of hypoxia-inducible factors (HIF-1 α and HIF-2 α) and vascular endothelial growth factor (VEGF) in the Persian sturgeon fingerlings (Acipenser persicus). J. Aqu. Eco.. 2016; 6 (3) :84-92
URL: http://jae.hormozgan.ac.ir/article-1-311-en.html


Volume 6, Issue 3 (winter 2016) Back to browse issues page
نشریه علمی بوم شناسی آبزیان Journal of Aquatic Ecology
Persian site map - English site map - Created in 0.05 seconds with 31 queries by YEKTAWEB 3660