In the recent years, water pollution by contaminations are increasing rapidly, the problems of aquatic pollution with heavy metals which is one of the important pollutions indicate that necessary to assess in fish as an important source of human food. The aim of this study was investigated the sub-lethal effects of zinc chloride on hepatic enzymes activity in grey mullet (Mugil Cephalus). In this study after determining the LC₅₀, Two sub-lethal treatments of zinc chloride includes (1.73 and 3.46 mg/L) was considered that any treatment has three replications. Fish were exposed to different doses of sub-lethal for 1, 7, 14 and 21 days and the end of each period samples of liver tissue was taken. The results showed that with increasing concentration of sub-lethal levels of aspartate aminotransferase (AST), alkaline phosphatase (ALP) and alanine aminotransferase (ALT) significantly increased (P≤0.05). Also with the prolonged exposure amount of enzymes AST, AST and ALT were increased significantly (P≤0.05). Results of this research showed those hepatic enzymes as stress indicator can be important factors to the investigation of eco-toxicological changes.

Keywords: Zinc Chloride, Hepatic enzymes, Mugil Cephalus

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