[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 6, Issue 3 (winter 2016) ::
J. Aqu. Eco. 2016, 6(3): 75-83 Back to browse issues page
Histopathological Changes of Zebrafish (Danio rerio) Ovaries Exposed to Sub-lethal Concentrations of Methyl Paraben
Nasrin Hassanzadeh *
associate professor malayer university
Abstract:   (1353 Views)
Paraben compounds are used widely as preservatives to inhibit microbial growth and extend used in pharmaceuticals, hygienic, cosmetics, care products. They pose the potential for reproductive toxicity for users. This paper provides an overview of the applications of histopathological biomarkers in reproductive toxicity in zebrafish caused by methylparaben. The present study investigated the changes in ovarian histopathology and Gonad Somatic Index (GSI) in zebrafish (Danio rerio) adult female after exposure to 0.001, 0.01, 1 and 10 mg/L methylparaben for 3 weeks in semi-static condition. Histological preparations were stained with Hematoxylin & Eosin. The results showed that Treatment at 0.001 to 10 mg/L of methylparaben had no significant effect on the survival, and condition factor. But in all treatments, GSI decreased and ovarian complications include wrinkled ooplasm, impaired yolk production, granulomatous inflammation and proteinaceous fluid were observed in the interstitial space of treated zebrafish ovaries. Also, atresia of vitellogenic oocytes was determined. These data show that an increase in atretic follicles has negative effects on zebrafish fertility and continuous exposure to subacute sublethal concentrations of methylparaben increase estrogenic and irreversible effects on the reproductive in female zebrafish.
Keywords: Dano rerio, histological biomarkers, reproductive toxicity, methyl paraben
Full-Text [PDF 911 kb]   (613 Downloads)    
Type of Study: Research | Subject: Special
Received: 2016/08/4 | Accepted: 2016/10/6 | Published: 2017/05/7
Send email to the article author

Add your comments about this article
Your username or Email:

Write the security code in the box >

XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Hassanzadeh N. Histopathological Changes of Zebrafish (Danio rerio) Ovaries Exposed to Sub-lethal Concentrations of Methyl Paraben . J. Aqu. Eco.. 2016; 6 (3) :75-83
URL: http://jae.hormozgan.ac.ir/article-1-468-en.html

Volume 6, Issue 3 (winter 2016) Back to browse issues page
نشریه علمی بوم شناسی آبزیان Journal of Aquatic Ecology
Persian site map - English site map - Created in 0.06 seconds with 31 queries by YEKTAWEB 3656