Cytotoxic activityof cyanobacteria from Geno hot spring on HeLa human cell line

Ebrahimi, Hadiseh; Akbarzadeh, Arash; Esmaeili, Mohamad Ali; Yousefzadi, Morteza

Volume 5, Issue 3 (Winter 2016) J. Aqua. Eco 2016, 5(3): 31-40 | Back to browse issues page

‎ 20.1001.1.23222751.1394.5.3.4.9

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Ebrahimi H, Akbarzadeh A, Esmaeili M A, Yousefzadi M. Cytotoxic activityof cyanobacteria from Geno hot spring on HeLa human cell line. J. Aqua. Eco 2016; 5 (3) :31-40
URL: http://jae.hormozgan.ac.ir/article-1-209-en.html

Cytotoxic activityof cyanobacteria from Geno hot spring on HeLa human cell line

Hadiseh Ebrahimi

, Arash Akbarzadeh ^*

, Mohamad Ali Esmaeili

, Morteza Yousefzadi

Abstract: (5392 Views)

The present study aimed to determine the cellular toxicity and anticancer characteristics of six species of Cyan bacteria living in Geno hot spring on cervical cancer cell lines. For this purpose, the cyto toxicity of methanol extracts from Geno hot spring Cyanobacteria including Leptolyngbya tenuis, Chroococcus minutes, Gloeocapsarupestris, Oscillatoria articulate, Chroococcus namiculata and Synechocystisa quatilis were examined in five different levels including 10, 25, 50, 75 and 100 Mg/ml and in 3 replications. The results showed that the toxicity effects of extracts from each species in different levels on cervical cancer cell line (HeLa) were significantly different (p< 0.05).The most effective species for killing Cervical cancer cells was G. rupestris (IC₅₀= 68.5672). Among all six algae used in the present study, only3 species including G. rupestris, S. aquatilis and L. tenuis had lethal effects for cervical cancer cells and the 3 other species had no effects.